Effects of nocturnal intermittent hypoxia on metabolic syndrome in Japanese adults without abdominal obesity
Main finding · Incident MetSResult — go to the resultRelative risk 2.10 95% CI 1.18–3.76Authors' conclusion
Nocturnal intermittent hypoxia was associated with an increased risk of developing MetS and some of its components in younger individuals without abdominal obesity.
Study context
- Population
- Japanese adults without baseline metabolic syndrome (MetS) and abdominal obesity (waist circumference <90 cm in men, <80 cm in women)
- Participants
- 647 adults
- Exposure
- 3% oxygen desaturation index (ODI) ≥5 vs lower 3% ODI
- Outcome
- Incident MetS (modified National Cholesterol Education Program Adult Treatment Panel III criteria) and its components
- Follow-up
- Five-year ; median 5.0 years (IQR, 4.8-5.1)
Methodological detailslongitudinal, stratified by age group (<65 years vs ≥65 years), modified Poisson regression
- Longitudinal
- Stratified by age group (<65 years vs ≥65 years)
- Modified Poisson regression
Main finding
Incident MetS
Relative risk
2.10
95% CI 1.18–3.76
3% ODI ≥5vs lower 3% ODI
RR 2.10 (95% CI 1.18–3.76)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Abdominal obesity, younger age group
| RR (95% CI) | ||
|---|---|---|
| 3% ODI ≥ 5 | 2.17 (1.42–3.33) | |
| 0.20.5125Relative risk (log scale) |
Low HDL-C, younger age group
| RR (95% CI) | ||
|---|---|---|
| 3% ODI ≥ 5 | 2.01 (1.02–3.96) | |
| 0.20.5125Relative risk (log scale) |
Hypertriglyceridemia, younger age group
| RR (95% CI) | ||
|---|---|---|
| 3% ODI ≥ 5 | 2.41 (1.35–4.30) | |
| 0.20.5125Relative risk (log scale) |
Original publication
Effects of nocturnal intermittent hypoxia on metabolic syndrome in Japanese adults without abdominal obesity. Int J Obes (Lond). Published 19 September 2026. doi:10.
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