Effects of metabolic parameters’ variability on cardiovascular outcomes in diabetic patients
Authors' conclusion
Variability of SBP, TC, TG and glucose are important residual risk factors for cardiovascular events in diabetic patients.
Study context
- Population
- Diabetic patients with ≥ 3 measurements of systolic blood pressure (SBP), blood glucose, total cholesterol (TC) and triglyceride (TG) over a minimum of three years at three tertiary general hospitals
- Participants
- 22,310 patients
- Exposure
- High vs low visit-to-visit variability of SBP, TC, TG and glucose
- Outcome
- Incidence of major adverse cardiovascular events (MACE): composite of cardiovascular death, MI and stroke
Methodological detailsmulticentre (three tertiary general hospitals), multivariable Cox regression
- Multicentre (three tertiary general hospitals)
- Multivariable Cox regression
Main finding
As reported in the abstract
MACE
High SBP-CV vs Low SBP-CV
Estimate (95% CI)P value
Hazard ratiomultivariable Cox regression
1.79(1.54–2.07)
P < 0.01High TC-CV vs Low TC-CV
Estimate (95% CI)P value
Hazard ratiomultivariable Cox regression
1.54(1.34–1.77)
P < 0.01High TG-CV vs Low TG-CV
Estimate (95% CI)P value
Hazard ratiomultivariable Cox regression
1.15(1.01–1.31)
P = 0.040High glucose-CV vs Low glucose-CV
Estimate (95% CI)P value
Hazard ratiomultivariable Cox regression
1.61(1.40–1.86)
P < 0.01Observational data: associations, not effects.
Original publication
Effects of metabolic parameters’ variability on cardiovascular outcomes in diabetic patients. Cardiovasc Diabetol. Published 15 May 2023. doi:10.
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