Effects of combined treatment of probiotics and metformin in management of type 2 diabetes: A systematic review and meta-analysis
Authors' conclusion
The addition of probiotics to metformin therapy is associated with improvement in T2DM outcomes. However, high-quality and adequately reported RCTs are needed in the future to confirm our findings.
Study context
- Population
- Adults with T2D; Randomized controlled trials (RCTs) from MEDLINE and EMBASE, inception to February 202317 comparisons
- Participants
- 1,009 adults14 RCTs
- Comparison
- Metformin plus probiotics vs metformin alone
- Outcome
- Fasting glucose and HbA1c
Methodological detailsrandom effects model
- Random effects model
Pooled result
As reported in the abstract
Each group vs metformin aloneEstimate (95 % CI)
Metformin + probiotics
MD (fasting glucose) −0.64(−1.06 to −0.22)
Metformin + probiotics
MD (HbA1c) −0.29(−0.47 to −0.10)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effects of combined treatment of probiotics and metformin in management of type 2 diabetes: A systematic review and meta-analysis. Diabetes Res Clin Pract. Published 25 June 2023. doi:10.
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