Effects of combined aerobic and resistance training on the inflammatory profile of children with overweight/obesity: A randomized clinical trial
Authors' conclusion
This exercise programme failed to improve the inflammatory profile in prepubertal children with overweight/obesity. Future studies should explore the effect of longer exercise interventions and in combination with diet.
Study context
- Population
- Prepubertal children with overweight or obesity (10.1 ± 1.1 years, 41% girls)
- Participants
- 109 children
- Comparison
- 20-week combined aerobic and resistance exercise training vs control
- Primary endpoint
- Inflammatory profile: plasma adiponectin, CRP, epidermal growth factor, IGF-1, IL-1β, IL-6, leptin, TNF-α, vascular endothelial growth factor A (VEGFA); total white blood cell (WBC) count and immune subpopulations
- Follow-up
- 20 weeks
Primary result
As reported in the abstract
Inflammatory biomarkers
- No intervention effect for any of the analysed biomarkers
- Exercise vs Control: all p ≥ 0.05
Further findings
Meaningful reduction in IL-1β (≥0.2 SD) (girls)
P = 0.01
| Outcome | Mean Z-score difference (95% CI) |
|---|---|
| IL-1β levels (girls)Girls; no significant effect in boys | 0.66 (0.32–1.01) |
IL-1β: sex by intervention interaction
- Significant sex by intervention interaction for IL-1β
- P = 0.03
Original publication
Effects of combined aerobic and resistance training on the inflammatory profile of children with overweight/obesity: A randomized clinical trial. Pediatr Obes. Published 31 July 2024. doi:10.
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