Effects of Aerobic Exercise on Systemic Insulin Degludec Concentrations in People with Type 1 Diabetes
Authors' conclusion
A single bout of aerobic exercise increases systemic IDeg exposure in adults on a stable basal IDeg regimen. This finding may have important implications for future hypoglycemia mitigation strategies around physical exercise in IDeg-treated patients.
Study context
- Population
- Male adults with T1D on stable insulin degludec (IDeg) regimen (age 30.7 ± 8.0 years, HbA1c 6.9 ± 0.7%)
- Participants
- 15 male adults
- Exposure
- IDeg concentrations during and after aerobic exercise vs baseline
- Aerobic exercisen = 15
- Outcome
- Systemic IDeg concentrations (high-resolution mass-spectrometry) during exercise vs baseline
- Follow-up
- Every 15 minutes at rest, during 60 minutes of cycling and until 90 minutes after exercise
Main finding
As reported in the abstract
Systemic IDeg concentration vs baseline · during 60-minute exercise
- Systemic IDeg increased during exercise over time vs baseline
- P < .001
- IDeg above baseline after 45 minutes
- 17.9%
- IDeg above baseline after 60 minutes
- 17.6%
Observational data: associations, not effects.
Further findings
IDeg concentration after exercise · 90 minutes after exercise termination
- IDeg remained elevated, above baseline at 90 minutes after exercise termination
- 14%
- P
- P < 0.001
Original publication
Effects of Aerobic Exercise on Systemic Insulin Degludec Concentrations in People with Type 1 Diabetes. J Diabetes Sci Technol. Published 30 September 2021. doi:10.
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