Effects of a 2‐Year Primary Care Weight Loss Intervention on Quality of Life in Patients With Obesity
Authors' conclusion
Weight loss was associated with improvements in HRQoL, and race differences were identified in changes in weight-related QoL, highlighting the need for precision medicine approaches to weight loss.
Study context
- Population
- Patients with obesity in 18 primary care clinics
- Participants
- 803 patients18 clinics
- Comparison
- Association of weight loss with health-related quality of life (HRQoL) change; 24-month intensive lifestyle intervention vs usual care
- Primary endpoint
- Association between weight loss and changes in HRQoL (generic HRQoL and weight-related QoL)
- Follow-up
- Baseline to 24 months
Methodological detailsrepeated-measures linear multilevel models
- Repeated-measures linear multilevel models
Primary result
As reported in the abstract
Improvement in weight-related QoL by weight loss category
Weight loss <5%
7.4
CI 5.1–9.7
Weight loss 5% to <10%
15.0
CI 11.4–18.5
Weight loss ≥10%
18.9
CI 15.4–22.4
Further findings
Generic HRQoL domains by weight loss
- Greater weight loss related to greater improvements in most generic HRQoL domains
Treatment response heterogeneity by race and sex
- Changes in generic HRQoL did not differ by race or sex; weight-related QoL did not differ by sex
- Black patients had less improvement in weight-related QoL vs other races
Original publication
Effects of a 2‐Year Primary Care Weight Loss Intervention on Quality of Life in Patients With Obesity. Obesity (Silver Spring). Published 4 April 2026. doi:10.
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