Effects of a 2-Year Early Childhood Vitamin D<sub>3</sub> Intervention on Tooth Enamel and Oral Health at Age 6–7 Years
Authors' conclusion
Daily supplementation with 10 µg vitamin D3 in the Northern Hemisphere seems adequate in healthy children younger than 2 years in ensuring good oral health at early school age.
Study context
- Population
- Children aged 6–7 years (median age 7.4 years, 51% boys) who received vitamin D3 supplementation in infancy in a trial of 975 healthy infants (2013–2016)56% in 30 µg
- Participants
- 123 children
- Comparison
- Vitamin D3 30 µg/day vs 10 µg/day from age 2 weeks to 2 years
- Primary endpoint
- Oral health: developmental defect of enamel, caries, oral rinse active matrix metalloproteinase-8 levels and tooth eruption
- Follow-up
- Age 6–7 years
Methodological detailsdouble-blind, outcome assessors blinded to intervention group
- Double-blind
- Outcome assessors blinded to intervention group
Primary result
As reported in the abstract
Developmental defect of enamel (DDE)
P = 0.104
Further findings
Vitamin D sufficient (25(OH)D ≥50 nmol/L) and caries-free teeth, all children · age 6–7 years
- Vitamin D sufficient (25(OH)D ≥50 nmol/L)
- 94%
- Caries-free teeth
- 88%
Original publication
Effects of a 2-Year Early Childhood Vitamin D<sub>3</sub> Intervention on Tooth Enamel and Oral Health at Age 6–7 Years. Horm Res Paediatr. Published 6 December 2022. doi:10.
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