Cardiovascular Risk Factors in Children and Adolescents with Type 1 Diabetes Mellitus: The Role of Insulin Resistance and Associated Genetic Variants
Authors' conclusion
Insulin resistance and T2D risk-associated genetic variants influence insulin sensitivity and known CVRFs in children and adolescents with T1D.
Study context
- Population
- Children and adolescents with T1D (174 males; mean age 15.7 ± 3.5 years)
- Participants
- 330 children
- Outcome
- Association of a 6-variant insulin resistance/T2D genetic risk score (GRS) with insulin sensitivity and known CVRFs
Main finding
As reported in the abstract
Association of GRS with phenotypes (multivariate regression)
- Estimated insulin sensitivity: β (95% range) −0.040 to −0.013, R2 = 0.86, p≤ 0.001
- −0.027
- Diastolic blood pressure: β [0.08-1.27], R2 = 0.20, p = 0.026
- 0.68
- Triglycerides: β [1.74-6.77], R2 = 0.13, p = 0.001
- 4.26
- Waist to height ratio: β [0.001-0.006], R2 = 0.75, p = 0.010
- 0.003
- Non-HDL-cholesterol: β [1.39-5.87], R2 = 0.12, p = 0.002
- 3.63
- Cardiovascular risk score (CVRS): β [0.008-0.118], R2 = 0.19, p = 0.025
- 0.063
Observational data: associations, not effects.
Further findings
Discrimination of subjects with more cardiovascular risk factor (CVRFs): clinical risk factors + genetic risk score (GRS) vs clinical risk factors alone
- C-statistic with GRS
- 0.89 (95% CI 0.84-0.95)
- C-statistic without GRS (0.73-0.93)
- 0.83
- Comparison P
- P = 0.037
Original publication
Cardiovascular Risk Factors in Children and Adolescents with Type 1 Diabetes Mellitus: The Role of Insulin Resistance and Associated Genetic Variants. Horm Res Paediatr. Published 22 November 2022. doi:10.
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