Gestational diabetes & diabetes in pregnancy
The effectiveness of pharmacological and lifestyle interventions to reduce the risk of diabetes and hyperglycaemia following gestational diabetes: A systematic review and meta‐analysis
Authors' conclusion
Although possibly due to chance, interventions to reduce hyperglycaemia after GDM may be effective. Future research should improve understanding of how interventions affect glucose control and how to optimise interventions for this population.
Study context
- Population
- Women with current or previous gestational diabetes mellitus (GDM), postpartum
- Participants
- 8,624 women31 studies
- Comparison
- Pharmacological or lifestyle interventions after GDM
- Outcome
- Relative risk of T2DM or continuous measures of glycaemia, change or at follow-up
Methodological detailsmeta-regression, 26 studies in meta-analyses, Two-thirds of studies followed up participants at 1 year or less
- Meta-regression
- 26 studies in meta-analyses
- Two-thirds of studies followed up participants at 1 year or less
Pooled result
As reported in the abstract
Risk of T2DM
Relative risk (95% CI)
Pharmacological interventionsn = 6 studies
0.80(0.64–1.00)
Lifestyle interventionsn = 12 studies; smaller effect size
0.88(0.76–1.01)
Further pooled results
FPG and other continuous glycaemic outcomes
- Dietary and physical activity interventions associated with a small reduction in FPG, particularly in longer interventions
- Inconsistent effects for other continuous outcomes
Original publication
The effectiveness of pharmacological and lifestyle interventions to reduce the risk of diabetes and hyperglycaemia following gestational diabetes: A systematic review and meta‐analysis. Diabet Med. Published 29 March 2024. doi:10.
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