Effect of Postmenopausal Hormone Therapy on Glucose Regulation in Women With Type 1 or Type 2 Diabetes: A Systematic Review and Meta-analysis
Authors' conclusion
When postmenopausal HT is considered for menopausal symptoms in women with type 2 diabetes, HT is expected to have a neutral-to-beneficial impact on glucose regulation. Evidence for the effect of postmenopausal HT in women with type 1 diabetes was limited.
Study context
- Population
- Postmenopausal women (≥12 months since final menstrual period) with T1D or T2D; 4.0% had T1D
- Participants
- 1,412 women19 randomized controlled trials (RCTs)
- Comparison
- Postmenopausal hormone therapy (HT) vs control
- Outcome
- HbA1c, fasting glucose, postprandial glucose and use of glucose-lowering drugs
Methodological details12 parallel-group and 7 crossover trials, 50% of included studies at high risk of bias
- 12 parallel-group and 7 crossover trials
- 50% of included studies at high risk of bias
Pooled result
As reported in the abstract
HbA1c
MD, % (95% CI)
HT
−0.56(−0.80 to −0.31)
MD, mmol/mol (95% CI)
HT
−6.08(−8.80 to −3.36)
Further pooled results
Fasting glucose
| MD (mmol/L) (95% CI) | ||
|---|---|---|
| HT | −1.15 (−1.78 to −0.51) | |
| −2−101Difference, mmol/L (linear scale) |
Original publication
Effect of Postmenopausal Hormone Therapy on Glucose Regulation in Women With Type 1 or Type 2 Diabetes: A Systematic Review and Meta-analysis. Diabetes Care. Published 20 September 2023. doi:10.
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