Gestational diabetes & diabetes in pregnancy
Effect of the interaction between advanced maternal age and pre-pregnancy body mass index (BMI) on pre-eclampsia and gestational diabetes mellitus (GDM) in Central China
Authors' conclusion
Advanced maternal age and pre-pregnancy BMI were respectively associated with the risk of pre-eclampsia/GDM, and there was an interaction between the two risk factors. In addition, we found that pre-pregnancy BMI served as a mediator of the association between advanced maternal age and the risk of pre-eclampsia/GDM, providing an essential target for the prevention of maternal overweight/obesity.
Study context
- Population
- Pregnant women, Central China
- Exposure
- Advanced maternal age and pre-pregnancy overweight/obesity vs their absence
- Outcome
- Pre-eclampsia and GDM
Methodological detailslogistic regression, causal mediation analysis
- Logistic regression
- Causal mediation analysis
Main finding
As reported in the abstract
- Pre-eclampsia, cases
- 788 (2.31%)
- GDM, cases
- 5430 (15.92%)
- Advanced maternal age and pre-eclampsia, aOR
- 1.74 (1.49-2.05) (95% CI)
- Advanced maternal age and GDM, aOR
- 1.76 (1.65-1.89) (95% CI)
- Pre-pregnancy overweight/obesity and pre-eclampsia, aOR
- 3.64 (3.12-4.24) (95% CI)
- Pre-pregnancy overweight/obesity and GDM, aOR
- 1.71 (1.60-1.85) (95% CI)
- Interaction between maternal age and pre-pregnancy BMI for pre-eclampsia/GDM
- all p for interaction <0.001
Observational data: associations, not effects.
Further findings
Mediation by pre-pregnancy BMI
- Pre-pregnancy BMI mediated the associations between maternal age and pre-eclampsia and GDM
Original publication
Effect of the interaction between advanced maternal age and pre-pregnancy BMI on pre-eclampsia and GDM in Central China. BMJ Open Diabetes Res Care. Published 21 April 2023. doi:10.
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