Effect of Methimazole Withdrawl Period on the I-131 Uptake Estimation Using Tc-99 m Thyroid Scanning in Graves’ Disease
Authors' conclusion
Estimated 131IU24h based on 99mTcTU is not suitable for GD patients with MWP less than 2 weeks at our institution, necessitating further prospective multicenter studies for validation.
Study context
- Population
- Graves' disease (GD) patients scheduled for 131I therapy, April 2022–April 2023
- Participants
- 116 patients
- Comparison
- Estimated vs measured 24-h 131I uptake across methimazole withdrawal periods
- Outcome
- Feasibility and reliability of 99mTcTU-based 131IU24h estimation with different MWPs
Methodological detailssingle-centre
- Single-centre
Performance
As reported in the abstract
Correlation and agreement between estimated and measured 131IU24h
| Test or model | R | P | Agreement 95% CI |
|---|---|---|---|
| MWP3 | 0.66 | P = .002 | −15.86 to 15.52% |
MWP3
R0.66
PP = .002
Agreement 95% CI−15.86 to 15.52%
- Estimation algorithm (standard group): estimated 131IU24h = 11.3ln (99mTcTU20min) + 39.4
- R2 = 0.62
- Correlation weak in MWP1 and MWP2
- both P > .05
Further findings
| Outcome | MWP1 | MWP2 | MWP3 | P value |
|---|---|---|---|---|
| 131IU24hMWP1 vs MWP2 · higher with MWP1 | mean 70.22 ± 7.95 % | mean 61.92 ± 9.84 % | — not stated in the abstract | P = 0.001 |
| Thyroid massMWP1 vs MWP3 · greater with MWP1 | mean 36.15 ± 22.38 g | — not stated in the abstract | mean 21.25 ± 11.90 g | P = 0.005 |
— not stated in the abstract
Original publication
Effect of Methimazole Withdrawl Period on the I-131 Uptake Estimation Using Tc-99 m Thyroid Scanning in Graves’ Disease. J Clin Endocrinol Metab. Published 11 November 2024. doi:10.
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