Effect of Impaired Awareness of Hypoglycemia on Glucose Decline During and After Exercise in the T1DEXI Study
Main finding · Glucose decline during exerciseResult — go to the resultAdjusted group difference −4.2 mg/dL 95% CI −8.4 to 0.05Authors' conclusion
Individuals with IAH have a higher underlying risk of hypoglycemia than "aware" individuals. Exercise does not appear to differentially increase risk for hypoglycemia during the activity, or in the subsequent 24 hours for IAH compared to aware individuals with T1D.
Study context
- Population
- Adults with T1D4,236 exercise sessions
- Participants
- 95 vs 95
- Exposure
- Impaired awareness of hypoglycemia (IAH) vs aware adults with T1D
- IAHn = 95
- Awaren = 95reference
- Outcome
- Change in continuous glucose monitoring (CGM)-measured glucose during exercise
- Follow-up
- During exercise
Methodological detailssecondary analysis of the T1DEXI Study, matched on sex, age, insulin delivery modality and HbA1c
- Secondary analysis of the T1DEXI Study
- Matched on sex, age, insulin delivery modality and HbA1c
Main finding
Glucose decline during exercise
Adjusted group difference
−4.2 mg/dL
95% CI −8.4 to 0.05
P = 0.051
By group
IAH
−21
± 44 · mg/dL
Aware
−19
± 43 · mg/dL
As reported in the abstract
Observational data: associations, not effects.
Further findings
Days with hypoglycemic event (≥15 min <70 mg/dL), exercise days · 24 h following exercise
P = 0.006
Days with hypoglycemic event (≥15 min <70 mg/dL), sedentary days
P = 0.001
Increased odds of hypoglycemic event <70 mg/dL with IAH: exercise vs sedentary days
- Did not differ significantly between exercise and sedentary days
- interaction P = .36
Original publication
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