Effect of exercise on plasma insulin levels in individuals with type 1 diabetes: A systematic review and meta‐analysis
Pooled result · Rapid-acting insulin levelsResult — go to the resultMD 18.44 pmol/L 95% CI 0.02–36.86Authors' conclusion
A small-to-moderate increase of insulin levels in studies including rapid-acting insulin was found after a bout of physical exercise in individuals with type 1 diabetes. However, current gaps in high-quality evidence challenge our understanding of insulin kinetics around exercise.
Study context
- Population
- Individuals with T1D on rapid-acting or (ultra)long-acting insulin performing acute exercise
- Participants
- 186 individuals17 trials
- Comparison
- Acute exercise vs control condition
- Outcome
- Exercise-induced change in insulin levels
Methodological detailsrandomised cross-over studies (rapid-acting insulin), pre- and post-studies (long-acting insulin), DerSimonian and Laird random effect method, 12 of 17 studies on rapid-acting insulin (cross-over); 5 of 17 single-arm studies on (ultra)long-acting insulin, High risk of bias: 7 of 12 rapid-acting insulin studies and all single-arm studies
- Randomised cross-over studies (rapid-acting insulin)
- Pre- and post-studies (long-acting insulin)
- DerSimonian and Laird random effect method
- 12 of 17 studies on rapid-acting insulin (cross-over); 5 of 17 single-arm studies on (ultra)long-acting insulin
- High risk of bias: 7 of 12 rapid-acting insulin studies and all single-arm studies
Pooled result
Rapid-acting insulin levels · after 30 min of exercise
MD
18.44 pmol/L
95% CI 0.02–36.86
Exercisevs Control
MD 18.44 pmol/L (95% CI 0.02–36.86)
As reported in the abstract
Original publication
Effect of exercise on plasma insulin levels in individuals with type 1 diabetes: A systematic review and meta‐analysis. Diabetes Obes Metab. Published 26 November 2024. doi:10.
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