Effect of daily insulin delivery variability on glycemic outcomes in patients with type 1 diabetes mellitus using an automated insulin delivery system
Authors' conclusion
Variability in insulin delivery, especially AB and MB, affects glycemic control in T1DM. Monitoring and optimizing these components may improve AID system effectiveness.
Study context
- Population
- Patients with T1D using the MiniMed 780G automated insulin delivery (AID) system for over six months7,710 patient-days
- Participants
- 257 patients
- Exposure
- Adults vs Pediatric
- Adultsn = 236
- Pediatricn = 21
- Outcome
- Variability in insulin delivery components (30-day periods)
Main finding
As reported in the abstract
AB-V% (automated correction bolus variability)
36.9 %
BI-V% (basal insulin variability)
16.8 %
MB-V% (manual bolus variability)
19.1 %
Observational data: associations, not effects.
Further findings
- Mean time in range (TIR70-180) exceeded 70 % in both groups
Original publication
Effect of daily insulin delivery variability on glycemic outcomes in patients with type 1 diabetes mellitus using an automated insulin delivery system. Diabetes Res Clin Pract. Published 9 September 2025. doi:10.
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