Effect of Calorie Restricted Diet Versus Liraglutide on Intrapancreatic Fat Deposition in People With Obesity: A Pilot Study
Authors' conclusion
Both CRD and liraglutide significantly and similarly reduce pancreatic, liver, and visceral fat, while improving glycemic-related parameters in people with obesity. Preliminary findings suggest liver and visceral fat loss primarily drive improved insulin resistance, whereas pancreatic fat reduction may relate to subtler insulin dynamics changes, warranting further investigation.
Study context
- Population
- People with obesity
- Participants
- 23 vs 23
- Exposure
- Calorie restricted diet vs liraglutide
- Calorie restricted diet (CRD)n = 23
- Liraglutiden = 23
- Outcome
- Change in pancreatic fat fraction (PFF)
- Follow-up
- 24 weeks
Methodological detailsnonrandomized, sub-study of a registered trial
- Nonrandomized
- Sub-study of a registered trial
Main finding
As reported in the abstract
Change in PFF
- Significant and comparable reductions in pancreatic fat fraction (PFF) with both CRD and liraglutide (time effect: p < 0.001)
- CRD vs Liraglutide: interaction effect: p = 0.560
Observational data: associations, not effects.
Secondary outcomes
| Outcome | P value |
|---|---|
| Body weight, LFF, VFA, HbA1c, HOMA2-IR and ISIM | all interaction effects: p > 0.05 |
Body weight, liver fat fraction (LFF), visceral fat area (VFA), HbA1c, HOMA2-IR and ISIM
- Significant and similar improvements in both groups (all time effects: p < 0.001)
Regression of changes in adiposity vs glycemic parameters
- ΔHOMA2-IR positively associated with Δweight and ΔLFF but negatively with ΔPFF
- ΔISIM negatively associated with ΔVFA and positively with ΔPFF
Original publication
Effect of Calorie Restricted Diet Versus Liraglutide on Intrapancreatic Fat Deposition in People With Obesity: A Pilot Study. Obesity (Silver Spring). Published 24 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →