Early weight loss, diabetes remission and long-term trajectory after diagnosis of type 2 diabetes: a retrospective study
Main finding · Diabetes remission (cohort 1)Result — go to the resultHR for remission 4.2Authors' conclusion
Early weight loss of ≥10% in type 2 diabetes was associated with sustained glycaemic improvements, increasing by three to four times the rates of diabetes remission. Remission, in turn, more than weight loss was associated with a reduced risk of complications.
Study context
- Population
- People with newly diagnosed T2D in routine care; 58% male, mean age 62 years, mean diabetes duration <2 years, mean baseline HbA1c 57–64 mmol/mol (7.4–8.0%), mean BMI ≈30 kg/m²cohorts of 1934 and 13,277
- Exposure
- Weight loss ≥10% vs <10% after T2D diagnosis
- Outcome
- Diabetes remission (cohort 1)
- Follow-up
- Up to 25 years
Methodological detailstwo cohorts, routine care setting
- Two cohorts
- Routine care setting
Main finding
As reported in the abstract
HR for remission
4.2
By group
Observational data: associations, not effects.
Further findings
Diabetes remission (cohort 2) · follow-up up to 10 years
HR for remission 2.6
| Outcome | aHR for new-onset microangiopathy (95% CI) | P value | |
|---|---|---|---|
| New-onset microangiopathy by remissionRemissionvs No remission | 0.84 (0.73–0.97) | P = 0.019 | |
| 0.512AHR for new-onset microangiopathy (log scale) |
| Outcome | Estimate |
|---|---|
| HbA1c (cohort 1)Sustained reduction in HbA1c with ≥10% (0.19%) | mean difference 2.1 mmol/mol |
| Remission by weight-loss category (cohort 1, sensitivity analysis)Weight loss ≥10% vs Weight loss <5% · <5% reference · sensitivity analysis | HR for remission 5.2 |
| Remission by weight-loss category (cohort 1, sensitivity analysis)Weight loss 5% to <10% vs Weight loss <5% · <5% reference · sensitivity analysis | HR for remission 1.7 |
CV risk factors
- Weight loss ≥10% improved systolic BP, HDL-C and TG
Remission by weight-loss category (cohort 1, sensitivity analysis)
- 5% to <10% weight loss: marginal improvements in HbA1c, lipids and remission vs <5%, inferior to ≥10%
Complications
- Weight loss ≥10% not associated with reduced incidence of complications
Original publication
Early weight loss, diabetes remission and long-term trajectory after diagnosis of type 2 diabetes: a retrospective study. Diabetologia. Published 22 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →