Early Pregnancy Plasma Per- and Polyfluoroalkyl Substances (PFAS) and Maternal Midlife Adiposity
Authors' conclusion
Select PFAS, assessed in pregnancy, may differentially affect maternal midlife adiposity, influencing later-life maternal cardiometabolic health.
Study context
- Population
- Project Viva participants with early pregnancy plasma concentrations of 6 PFAS (mean gestation 10.0 weeks; mean age 32.5 years) and midlife adiposity outcomes (mean age 50.7 years)
- Participants
- 547 participants
- Exposure
- Early pregnancy plasma PFAS concentrations (individual and mixture) and maternal midlife adiposity
- Outcome
- Midlife adiposity: weight, WC, trunk fat mass (TFM), total body fat mass (TBFM)
- Follow-up
- Mean 17.7 years
Methodological detailsProject Viva, linear regression, Bayesian Kernel Machine Regression (BKMR)
- Project Viva
- Linear regression
- Bayesian Kernel Machine Regression (BKMR)
Main finding
As reported in the abstract
Midlife adiposity
- Linear regression, weight per doubling of perfluorooctane sulfonate (PFOS)
- 3.8 kg (95% CI: 1.6, 5.9)
- Linear regression, weight per doubling of 2-(N-ethyl-perfluorooctane sulfonamido) acetate
- 2.3 kg (95% CI: 0.9, 3.7)
- BKMR, PFOS 25th vs 75th percentile, weight
- 7.7 kg (95% CI: 4.0, 11.5)
- BKMR, PFOS, trunk fat mass (TFM)
- 1.2 kg (95% CI: 0.0, 2.3)
- BKMR, PFOS, total body fat mass (TBFM)
- 3.0 kg (95% CI: 0.8, 5.2)
- BKMR, perfluorononanoate, weight
- −6.0 kg (95% CI: −8.5, −3.5)
- BKMR, perfluorononanoate, waist circumference (WC)
- −1.8 cm (95% CI: −3.2, −0.3)
- BKMR, perfluorononanoate, TFM
- −0.8 kg (95% CI: −1.5, −0.1)
- BKMR, perfluorononanoate, TBFM
- −1.4 kg (95% CI: −2.7, −0.3)
- BKMR, perfluorohexane sulfonate, TFM
- −0.8 kg (95% CI: −1.5, −0.1)
- BKMR, perfluorohexane sulfonate, TBFM
- −1.4 kg (95% CI: −2.6, −0.2)
Observational data: associations, not effects.
Original publication
Early Pregnancy Plasma Per- and Polyfluoroalkyl Substances (PFAS) and Maternal Midlife Adiposity. J Clin Endocrinol Metab. Published 5 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →