Early pregnancy biomarkers of inflammation and metabolic regulation in polycystic ovary syndrome
Authors' conclusion
Monocyte chemoattractant protein-1 and FABP4 concentrations were elevated in early pregnancy among women with PCOS, largely reflecting maternal adiposity. These markers did not modify associations between PCOS and pregnancy outcomes.
Study context
- Population
- Pregnant women (<24 weeks' gestation) at risk of GDM
- Participants
- 151 women
- Exposure
- Women with polycystic ovary syndrome (PCOS) vs without PCOS
- PCOSn = 65
- Without PCOSn = 86reference
- Outcome
- Early pregnancy markers of inflammation and metabolic regulation (CRP, TNF-α, interleukins, MCP1, FABP4, GDF-15, adipokines)
- Follow-up
- Early pregnancy
Methodological detailsinteraction analyses, pooled baseline data from 2 international multicenter clinical trials
- Interaction analyses
- Pooled baseline data from 2 international multicenter clinical trials
Main finding
As reported in the abstract
PCOS vs Without PCOSEstimate (95% CI)P value
Attenuated after adjustment for maternal age and BMI
GMR, MCP1 1.15(1.01–1.31)
P & .04Attenuated after adjustment for BMI
GMR, FABP4 1.32(1.04–1.68)
P & .02PCOS
GMR, FABP4, age-adjusted 1.34(1.05–1.71)
P & .02Observational data: associations, not effects.
Further findings
- MCP1 or FABP4 showed no interactions with maternal or neonatal outcomes
Original publication
Early pregnancy biomarkers of inflammation and metabolic regulation in polycystic ovary syndrome. J Clin Endocrinol Metab. Published 9 March 2026. doi:10.
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