Lipids & metabolic liver disease
Dyslipidemia Is Associated With Increased Natural Killer Cell Cytotoxicity and Autoimmunity in Women With Recurrent Pregnancy Losses
Authors' conclusion
A significant proportion of women with RPL have dyslipidemia, and the risk of autoimmune and cellular immune abnormalities is increased in women with a history of RPL and dyslipidemia.
Study context
- Population
- Women with recurrent pregnancy loss (RPL), university clinic
- Participants
- 115 women
- Exposure
- Dyslipidemia vs nondyslipidemia in women with RPL
- Dyslipidemian = 45
- Nondyslipidemian = 70reference
- Outcome
- Cellular immune activity and autoimmune parameters
Methodological detailsex vivo experiments, university clinic
- Ex vivo experiments
- University clinic
Main finding
As reported in the abstract
- Prevalence of dyslipidemia
- 45 (39.1%)
- Natural killer (NK) cell cytotoxicity at E:T 25:1 and 12.5:1 significantly higher with dyslipidemia
- P < .05
- NK cell cytotoxicities (E:Ts 25:1 and 12.5:1) positively correlated with serum total cholesterol and LDL-C
- all P < .05
Observational data: associations, not effects.
Further findings
Ex vivo oxidized low density lipoprotein (oxLDL) pretreatment of NK cells
- NK cell cytotoxicities significantly increased after pretreatment with 5 and 50 μg/mL oxLDL
- P < 0.05 each
- oxLDL pretreatment enhanced NK cell conjugation with target cells and increased perforin secretion
Original publication
Dyslipidemia Is Associated With Increased Natural Killer Cell Cytotoxicity and Autoimmunity in Women With Recurrent Pregnancy Losses. J Clin Endocrinol Metab. Published 15 May 2025. doi:10.
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