Dynamic Response of Musclin, a Myokine, to Aerobic Exercise and Its Interplay With Natriuretic Peptides and Receptor C
Authors' conclusion
Musclin's classification as a myokine is supported by its response to aerobic exercise and its association with LBM. Additionally, its interactions with NPR-C and NPs suggest its physiological relevance and potential clinical implications.
Study context
- Population
- Inactive young males undergoing moderate-intensity aerobic exercise
- Participants
- 21 males
- Outcome
- Dynamic response of serum musclin during and after aerobic exercise
- Follow-up
- During and after exercise
Main finding
As reported in the abstract
Serum musclin and its interplay with natrieutic peptides (NPs) and NPR-C
- Serum musclin increased significantly during aerobic exercise, declined during recovery, remaining elevated vs baseline
- Significant correlations between musclin responses and lean body mass
- Exercise-induced changes in musclin positively correlated with those of atrial natriuretic peptide (ANP)
- Potential interplay between natrieutic peptide receptor C (NPR-C) expression and musclin dynamics on ANP suggested
- Musclin's influence on lipid mobilization not predominant when considering other lipolytic factors during exercise
Original publication
Dynamic Response of Musclin, a Myokine, to Aerobic Exercise and Its Interplay With Natriuretic Peptides and Receptor C. J Clin Endocrinol Metab. Published 2 July 2024. doi:10.
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