DXA Derived Low Bone Mass in a Cohort of Prepubertal Eastern Indian Girls With Turner Syndrome Disappeared Following Adjustment for Short Stature
Authors' conclusion
When adjusted for stature, bone mineral density in Turner Syndrome is not different from that of healthy girls of the same age.
Study context
- Population
- Pre-pubertal Eastern Indian girls with Turner syndrome (TS) aged 12–18 years without prior GH or pubertal induction, and age-matched controls
- Participants
- 80 vs 85
- Exposure
- Prepubertal girls with TS vs healthy controls
- TSn = 80
- Controlsn = 85reference
- Outcome
- Bone-mineral-density (BMD) by DXA, with stature correction (bone mineral apparent density (BMAD), height-adjusted Z scores)
Methodological detailsage-matched controls, DXA stature corrections as per ISCD official positions
- Age-matched controls
- DXA stature corrections as per ISCD official positions
Main finding
As reported in the abstract
BMD
- Differences disappeared at all sites after adjustment for stature
- TS vs Controls: P < 0.001
- TS vs Controls: P = 0.002
- TS vs Controls: = 0.006
- TS vs Controls: P = 0.357
- TS vs Controls: P = 0.496
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Beta-CTX (bone resorption)0.81 ± 0.37 vs 1.05 ± 0.59 ng/mL; lower with TS | P = 0.036 |
Beta-CTX (bone resorption)
- Lower beta-CTX in TS indicated reduced bone resorption
Original publication
DXA Derived Low Bone Mass in a Cohort of Prepubertal Eastern Indian Girls With Turner Syndrome Disappeared Following Adjustment for Short Stature. Clin Endocrinol (Oxf). Published 31 December 2025. doi:10.
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