Duration of Diabetes, Glycemic Control, and Risk of Heart Failure Among Adults With Diabetes: A Cohort Study
Authors' conclusion
The risk of HF among individuals with diabetes increases with a longer duration of diabetes and increasing HbA1c levels. This finding may contribute to the individualized prevention of HF in patients with diabetes if being considered in clinical practices and policy-making.
Study context
- Population
- Individuals with diabetes but without heart failure (HF) at baseline recruitment of UK Biobank
- Participants
- 23,754 individuals
- Exposure
- Diabetes duration categories and hemoglobin A1c (HbA1c) categories vs lowest category
- Outcome
- Incident HF
Methodological detailsUK Biobank, multivariate Cox models adjusted for traditional risk factors
- UK Biobank
- Multivariate Cox models adjusted for traditional risk factors
Main finding
As reported in the abstract
Hazard ratio (95% CI)
Duration 5 to <10 yearsvs Duration <5 years
1.09(0.97–1.23)
Duration 10 to <15 yearsvs Duration <5 years
1.13(0.97–1.30)
Duration ≥15 yearsvs Duration <5 years
1.32(1.15–1.53)
HbA1c 53.0 to <58.5 mmol/molvs HbA1c <53.0 mmol/mol
1.15(1.02–1.31)
HbA1c 58.5 to <63.9 mmol/molvs HbA1c <53.0 mmol/mol
1.07(0.91–1.26)
HbA1c ≥63.9 mmol/molvs HbA1c <53.0 mmol/mol
1.46(1.30–1.65)
Observational data: associations, not effects.
Further findings
Joint effect: longest duration (≥15 years) and poorer glycemic control (HbA1c ≥63.9 mmol/mol [8.0%])
- Particularly higher risk of HF
- P for interaction = 0.026
Original publication
Duration of Diabetes, Glycemic Control, and Risk of Heart Failure Among Adults With Diabetes: A Cohort Study. J Clin Endocrinol Metab. Published 16 November 2022. doi:10.
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