Duration-dependent impact of cardiometabolic diseases and multimorbidity on all-cause and cause-specific mortality: a prospective cohort study of 0.5 million participants
Authors' conclusion
Among Chinese adults, mortality risk increased with the number of the CMDs and changed with prolonged disease duration, the patterns of which varied among the three CMDs.
Study context
- Population
- Adults aged 30–79, China Kadoorie Biobank; analysis among 463,178 participants free of three cardiometabolic diseases (CMDs) at baseline463,178 free of CMDs at baseline
- Participants
- 512,720 adults
- Exposure
- Cardiometabolic multimorbidity (CMM) vs no CMD during follow-up
- Outcome
- All-cause and cause-specific mortality
- Follow-up
- Median 12.1 years
Methodological detailstime-updated exposures
- Time-updated exposures
Main finding
As reported in the abstract
Mortality, CMM vs no CMD
CMM vs No CMDAdjusted hazard ratio (95% CI)
All-cause mortality
2.93(2.80–3.07)
Circulatory system disease mortality
5.05(4.74–5.37)
Respiratory system disease mortality
2.72(2.35–3.14)
Cancer mortality
1.30(1.16–1.45)
Other-cause mortality
2.30(2.02–2.61)
- Participants with at least one incident CMD
- 99,770
- Deaths
- 56,549
Observational data: associations, not effects.
Further findings
- All CMDs had high mortality risk in the first year of diagnosis
- With prolonged duration, risk increased for diabetes, decreased for IHD, and stayed high for stroke
- With CMM, estimates inflated but the pattern remained
Original publication
Duration-dependent impact of cardiometabolic diseases and multimorbidity on all-cause and cause-specific mortality: a prospective cohort study of 0.5 million participants. Cardiovasc Diabetol. Published 12 June 2023. doi:10.
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