Dorsal striatal response to taste is modified by obesity and insulin resistance
Authors' conclusion
These data support the hypothesis that insulin resistance and obesity contribute to aberrant responses to taste in the DS, which is only partially attenuated by weight loss. Aberrant responses to food exposure may be a barrier to weight loss.
Study context
- Population
- Three phenotypically distinct groups: metabolically healthy lean, metabolically healthy obesity and metabolically unhealthy obesity
- Comparison
- Metabolically healthy lean vs metabolically healthy obesity vs metabolically unhealthy obesity (MUO)
- Outcome
- Taste-induced activation in the caudate and putamen of the dorsal striatum (BOLD functional MRI)
Methodological detailsBlood oxygen level-dependent (BOLD) functional MRI, weight loss intervention in MUO
- BOLD functional MRI
- Weight loss intervention in MUO
Main finding
As reported in the abstract
Taste-induced BOLD response in the dorsal striatum · baseline
- Metabolically healthy lean: primarily positive BOLD response
- MUO: primarily negative BOLD response
- Metabolically healthy obesity: response in between the two other groups
Further findings
Food craving
- Food craving was predicted by taste-induced activation
Taste-induced activation in the dorsal striatum after weight loss (MUO)
- Taste-induced activation increased in the dorsal striatum after weight loss in MUO
Original publication
Dorsal striatal response to taste is modified by obesity and insulin resistance. Obesity (Silver Spring). Published 21 July 2023. doi:10.
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