Does the OP5 Automated Insulin Delivery System Close the Gap in Glycemic Control Between White and Black Youth with Type 1 Diabetes?
Authors' conclusion
Gaps in TIR and average CGM glucose between White and Black youth narrow with AID use, but do not close completely.
Study context
- Population
- Youth with T1D using OP5 at two pediatric academic centers; 61% female, mean age 11.6 years, 40% publicly insured, median T1D duration 2.9 years, mean hemoglobin A1c (HbA1c) 8.6%
- Participants
- 132 matched pairs
- Exposure
- Black vs White youth with T1D using OP5 automated insulin delivery (AID)
- Outcome
- Change in the White–Black gap in TIR, average CGM glucose and HbA1c
- Follow-up
- Baseline to 9 days and 90 days
Methodological detailstwo pediatric academic centers, unadjusted and adjusted models
- Two pediatric academic centers
- Unadjusted and adjusted models
Main finding
As reported in the abstract
9 days
- Time in range (TIR) gap: baseline 7.8% points decreased to 3.9% points
- P = 0.052
- Average continuous glucose monitor (CGM) glucose gap: 20.5mg/dL at baseline decreased to 8.0 mg/dL
- P = 0.012
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Time in automated mode · 90 daysLower in Black youth | P < 0.0001 |
| Boluses per day · 90 daysLower in Black youth | P < 0.0001 |
Gap reduction from baseline at 90 days
- No significant reduction in TIR gap
- P = 0.35
- No significant reduction in CGM glucose gap
- P = 0.09
Adjusted gaps (insurance, baseline insulin delivery method) · 9 days and 90 days
- No significant reduction in gaps at either 9 days or 90 days
- Adjusted
HbA1c
- All youth had decreases in HbA1c
TIR increase by prior insulin delivery method (multivariable) · 9 days and 90 days
- Greatest TIR increase in youth transitioning from MDI at 9 days
- P < 0.001
- Greatest TIR increase in youth transitioning from MDI at 90 days
- P < 0.01
Original publication
Does the OP5 Automated Insulin Delivery System Close the Gap in Glycemic Control Between White and Black Youth with Type 1 Diabetes? Diabetes Technol Ther. Published 2 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →