Does high‐normal blood pressure lead to excess cardiovascular disease events and deaths in Chinese people? A post‐hoc analysis of the 30‐year follow‐up of the Da Qing IGT and Diabetes Study
Authors' conclusion
This post-hoc study provided no evidence that the high-normal BP increased cardiovascular risk in the Da Qing study population, suggesting that it was reasonable to continue to define hypertension at 140/90 mmHg in China.
Study context
- Population
- Individuals from the original Da Qing IGT and Diabetes Study, China
- Participants
- 1,726 individuals
- Comparison
- High-normal BP and hypertension vs normal BP
- Primary endpoint
- CVD events
- Follow-up
- 30-year (1986–2016)
Methodological details30-year follow-up
- 30-year follow-up
Primary result
As reported in the abstract
30-year follow-up
Each group vs normal BPHazard ratio (95% CI)P value
High-normal BPadjusted for covariates
1.05(0.84–1.30)
P = 0.68Hypertension
1.91(1.48–2.46)
P < 0.0001Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Coronary heart disease · 30-year follow-upHigh-normal BPvs Normal BPAdjusted for covariates | 1.12 (0.77–1.63) | P = 0.57 | |
| Coronary heart disease · 30-year follow-upHypertensionvs Normal BP | 1.73 (1.12–2.67) | P = 0.01 | |
| Stroke · 30-year follow-upHigh-normal BPvs Normal BPAdjusted for covariates | 1.05 (0.82–1.34) | P = 0.71 | |
| Stroke · 30-year follow-upHypertensionvs Normal BP | 1.90 (1.43–2.52) | P < 0.0001 | |
| CVD deaths · 30-year follow-upHigh-normal BPvs Normal BPAdjusted for covariates | 1.15 (0.82–1.60) | P = 0.41 | |
| CVD deaths · 30-year follow-upHypertensionvs Normal BP | 2.07 (1.43–3.01) | P = 0.0001 | |
| 0.20.5125Hazard ratio (log scale) |
Cardiovascular disease (CVD) events by diabetes status (subgroups)
- Regardless of diabetes, high-normal BP did not increase CVD events vs normal BP
Original publication
Does high‐normal blood pressure lead to excess cardiovascular disease events and deaths in Chinese people? A post‐hoc analysis of the 30‐year follow‐up of the Da Qing IGT and Diabetes Study. Diabetes Obes Metab. Published 27 November 2023. doi:10.
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