Associations between complexity of glucose time series and cognitive function in adults with type 2 diabetes
Authors' conclusion
Decreased glucose complexity closely relates to cognitive dysfunction and olfactory brain activation abnormalities in diabetes.
Study context
- Population
- Adults with T2D who completed CGM and cognitive assessments; 139 underwent functional MRI139 with functional MRI
- Participants
- 449 adults
- Exposure
- CGI tertiles
- Outcome
- Mild cognitive impairment (MCI)
Main finding
As reported in the abstract
MCI by CGI tertile (multivariable-adjusted)
Each group vs tertile 1Odds ratio (95% CI)
Tertile 2
1.23(0.68–2.24)
Tertile 3
2.27(1.29–4.00)
Observational data: associations, not effects.
Further findings
Cognitive domains
- Decreased CGI associated with decline in executive function and attention
Brain imaging
- Decreased CGI: reduced olfactory activation in left orbitofrontal cortex (OFC) and disrupted functional connectivity between left OFC and right posterior cingulate gyrus
- Left OFC activation partially mediated the CGI–executive function association
- Mediation analysis
Original publication
Associations between complexity of glucose time series and cognitive function in adults with type 2 diabetes. Diabetes Obes Metab. Published 23 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →