Does diabetes modify the triglyceride–glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants
Authors' conclusion
TyG index showed association with cardiovascular events, mortality, and all-cause mortality independent of diabetic status, with low to moderate certainty. The associations for IHD and all-cause death were stronger in diabetic patients than in individuals without diabetes. Future studies should explore the role of diabetes in the TyG index-associated CVD outcomes and mortality.
Study context
- Population
- Participants with and without diabetes in cohort studies of the triglyceride-glucose (TyG) index and cardiovascular events and mortality; PubMed, Cochrane Library and Embase searched to December 2, 2024; mean age 31.46 years (DM 65.18; non-DM 31.23); 40.66% female
- Participants
- 7,239,790 participants50 cohort studies
- Comparison
- TyG index–CVD associations in DM vs non-DM
- Outcome
- Association between the TyG index and CVD risk, stratified by diabetes status, and modifying effect of diabetic status
Methodological detailsrandom effects model
- Random effects model
Pooled result
As reported in the abstract
Association of TyG index with outcomes by diabetes status (HR)
- Cardiovascular events; similar
- HR 1.72 vs. 1.55; P = 0.55
- Major adverse cardiovascular and cerebrovascular events; similar
- HR 2.02 vs. 1.91; P = 0.84
- Stroke; similar
- HR 1.46 vs. 1.39; P = 0.77
- Cardiovascular death; similar
- HR 1.85 vs. 1.60; P = 0.56
- IHD; stronger in DM
- HR 2.20 vs. 1.57; P = 0.03
- All-cause mortality; stronger in DM
- HR 1.94 vs. 1.24; P = 0.01
Original publication
Does diabetes modify the triglyceride–glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants. Cardiovasc Diabetol. Published 27 January 2025. doi:10.
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