Disparities of adiposity explained ethnic differences in insulin sensitivity and secretion traits in adolescents with normoglycaemia
Authors' conclusion
Disparities in adiposity could partially or fully explain the observed ethnic differences in insulin sensitivity and secretion traits. Our study provides new understandings regarding the contribution of adiposity in determining insulin sensitivity and secretion traits, and may provide novel insights on how adiposity may shape ethnic differences in metabolic profiles.
Study context
- Population
- Normoglycaemic adolescents (mean age 11.3 ± 1.2 years) from four ethnic groups, ten international centres, 2013–2016
- Participants
- 3,349 adolescents
- Exposure
- Ethnic groups vs Non-Hispanic Whites
- Outcome
- Variance of OGTT-derived insulin sensitivity and secretion traits explained by adiposity (BMI, waist-to-height ratio, fat mass index), and ethnic differences in these traits explained by adiposity
Methodological detailsmulti-ethnic cohort, multicentre (ten international centres)
- Multi-ethnic cohort
- Multicentre (ten international centres)
Main finding
As reported in the abstract
Hispanics
31.97% - 43.56%
Non-Hispanic Whites
18.09% - 24.80%
- Body mass index (BMI) disparities fully explained differences in insulin sensitivity and the sensitivity–secretion balance between Non-Hispanic Blacks and Non-Hispanic Whites
- pΔEMM > 0.05
- Adiposity disparities only partially explained ethnic differences in other comparisons
- pΔEMM < 0.05
Observational data: associations, not effects.
Original publication
Disparities of adiposity explained ethnic differences in insulin sensitivity and secretion traits in adolescents with normoglycaemia. Diabetes Res Clin Pract. Published 14 November 2025. doi:10.
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