Disparities in the Glycemic and Incretin Responses to Intraduodenal Glucose Infusion Between Healthy Young Men and Women
Authors' conclusion
Healthy young women exhibit comparable GIP but a markedly greater GLP-1 response to intraduodenal glucose than men. This disparity warrants further investigations to delineate the underlying mechanisms and may be of relevance to the reduced risk of diabetes in premenopausal women when compared to men.
Study context
- Population
- Healthy young males and females receiving intraduodenal glucose infusion at 2 kcal/min (Study 1: 9 women, 20 men) or 3 kcal/min (Study 2: 10 women, 26 men) for 60 minutes2 studies
- Comparison
- Healthy young women vs men
- Outcome
- Blood glucose and plasma insulin, GLP-1 and GIP responses (iAUC) to intraduodenal glucose
- Follow-up
- 0-60 minutes
Main finding
As reported in the abstract
iAUC0-60min responses to intraduodenal glucose
- 2 kcal/min: blood glucose and plasma GIP iAUC did not differ between groups
- 3 kcal/min: blood glucose, plasma GIP and insulin iAUC did not differ between women and men
- Women vs Men: P = 0.016
- Women vs Men: P = 0.011
- Women vs Men: P = 0.012
Original publication
Disparities in the Glycemic and Incretin Responses to Intraduodenal Glucose Infusion Between Healthy Young Men and Women. J Clin Endocrinol Metab. Published 29 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →