Obesity

Disparities in Prescription of Long‐Acting GLP‐1s

Obesity (Silver Spring)Published Retrospective pre-post study

Authors' conclusion

Black and Hispanic patients were less likely and patients with private insurance, diabetes, and established patient relationships were more likely to be prescribed Sema/Tirz. Racial and ethnic disparities in medication prescription were less apparent after a state Medicaid policy change to cover new GLP-1s.

Study context

Population
Patients at medical weight management appointments at a large tertiary care center, January and April 2024
Participants
2,060 patients
Exposure
Patient and appointment factors associated with Sema/Tirz prescription, before vs after MassHealth AOM coverage change
Outcome
Prescription of Sema/Tirz vs no or a different AOM
Methodological detailssingle tertiary care center
  • Single tertiary care center

Main finding

As reported in the abstract

Factors associated with Sema/Tirz prescription (multivariable analysis)

Private insurance, aOR

2.744

p < 0.001

Diabetes, aOR

2.507

p < 0.001

Established patient relationship, aOR

1.706

p < 0.001

Observational data: associations, not effects.

Further findings

Racial/ethnic differences in Sema/Tirz prescription by period

January 2024: Black patients less likely to be prescribed Sema/Tirz
49% (p = 0.003)
January 2024: Hispanic patients less likely to be prescribed Sema/Tirz
47% (p = 0.025)
April 2024, after MassHealth changes: only "Not Disclosed" race less likely to receive Sema/Tirz
P < 0.001

Original publication

Disparities in Prescription of Long‐Acting GLP‐1s. Obesity (Silver Spring). Published 2 March 2026. doi:10.1002/oby.70152

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