Differential Impact of Body Mass Index on Recurrence, Cardiac Remodelling, and Quality of Life After Atrial Fibrillation Ablation: Insights From the China‐ Atrial Fibrillation (AF) Registry
Authors' conclusion
Higher BMI exhibits a linear association with AF recurrence post-RFCA. Obesity is linked to nonlinear adverse remodelling (LVEDD and LVWT).
Study context
- Population
- First-time radiofrequency catheter ablation (RFCA) patients for AF, China-AF registry; median age 61.55 years, 32.6% female
- Participants
- 12,104 patients
- Exposure
- Body mass index (BMI) categories: obese and overweight vs under/normal weight
- Outcome
- AF recurrence
- Follow-up
- Median 47.5 months
Methodological detailsmultivariable Cox regression, median regression, restricted cubic splines, subgroup analyses
- Multivariable Cox regression
- Median regression
- Restricted cubic splines
- Subgroup analyses
Main finding
As reported in the abstract
Estimate (95% CI)
BMIlinear, dose-dependent association
fully adjusted HR 1.01(1.00–1.02)
Obesevs Under/normal weight
HR 1.16(1.05–1.28)
- Patients with AF recurrence
- 4932 (40.8%)
Observational data: associations, not effects.
Further findings
| Outcome | Difference (mm) (95% CI) | P value | |
|---|---|---|---|
| LVEDD (exploratory) · 12 monthsObesevs Under/normal weightNonlinear association | 2.17 (0.79–3.55) | pnonlinear < 0.05 | |
| LVWT (exploratory) · 12 monthsObesevs Under/normal weightNonlinear association | 0.81 (0.45–1.17) | pnonlinear < 0.05 | |
| −2024Difference, mm (linear scale) |
Original publication
Differential Impact of Body Mass Index on Recurrence, Cardiac Remodelling, and Quality of Life After Atrial Fibrillation Ablation: Insights From the China‐ AF Registry. Diabetes Obes Metab. Published 7 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →