Differential expression of coagulation pathway-related proteins in diabetic urine exosomes
Authors' conclusion
Coagulation-related proteins were expressed in urine exosomes. Among them, F2 was increased in diabetic urine exosomes and may be a potential biomarker for monitoring diabetic changes.
Study context
- Population
- Urine exosomes of diabetic patients and healthy controls
- Comparison
- Diabetic patients vs healthy controls
- Outcome
- Coagulation-related proteins in urine exosomes
Methodological detailsproteomic analysis (LC-MS/MS), validation by ELISA, mass spectrometry and western blotting
- Proteomic analysis (LC-MS/MS)
- Validation by ELISA, mass spectrometry and western blotting
Main finding
As reported in the abstract
- Coagulation-related proteins found in urine exosome proteomics
- 8
Further findings
Correlation of urine exosome F2 with clinical indicators
- F2 expression correlated with clinical lipid metabolism indexes; F2 concentration strongly positively correlated with blood TG
- P < 0.05
ROC curve analysis of urine exosome F2 for diabetes monitoring
- F2 protein in urine exosomes had good monitoring value for diabetes
Original publication
Differential expression of coagulation pathway-related proteins in diabetic urine exosomes. Cardiovasc Diabetol. Published 22 June 2023. doi:10.
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