Dietary Inflammatory Index and Mediterranean Diet Score are associated with systemic inflammation in women with lipedema
Authors' conclusion
A pro-inflammatory diet, as reflected by higher DII, is associated with increased systemic inflammation in lipedema. These findings highlight the potential role of anti-inflammatory dietary patterns, particularly the Mediterranean diet, as part of non-pharmacological strategies for managing inflammation in lipedema. These findings suggest that while dietary inflammatory potential influences systemic inflammation, its relationship with pain and quality of life remains unclear and warrants further interventional studies.
Study context
- Population
- Women with stage 2–3 lipedema and body mass index (BMI) 30–40 kg/m²
- Participants
- 60 women
- Outcome
- Association of DII and MDS with inflammatory biomarkers (TNF-α, IL-6)
Main finding
As reported in the abstract
- Dietary Inflammatory Index (DII) score positively associated with elevated TNF-α and IL-6 concentration
- p < 0.001
Observational data: associations, not effects.
Further findings
Pain (Visual Analog Scale (VAS)) and quality of life (SF-12)
- No significant associations between DII or Mediterranean diet scores (MDS) and pain (VAS) or quality of life (SF-12) scores
- Mental component scores slightly higher with moderate vs higher DII levels
Age and disease duration
- Age and disease duration not significant in any model
Original publication
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