Diabetes Insipidus as an Early Clinical Indicator of Wolfram Syndrome Type 1: Evidence From a Symptom‐Based Screening Approach
Authors' conclusion
Our findings suggest that DI may present before OA in WS1.
Study context
- Population
- Turkish children with T1Dchildren with T1D screened
- Participants
- 1,278 children
- Exposure
- Questionnaire-screened WS1 cases vs historical WS1 cases
- Screenedn = 6
- Historicaln = 7reference
- Outcome
- DI diagnosis and confirmed WS1 via questionnaire screening
Methodological detailssymptom-based questionnaire screening, genetic analysis of WFS1, comparison with historical case series and literature data
- Symptom-based questionnaire screening
- Genetic analysis of WFS1
- Comparison with historical case series and literature data
Main finding
As reported in the abstract
Patients considered to have diabetes insipidus (DI), eligible for WFS1 genetic analysis
18
Biallelic WFS1 variations, WS1 confirmed (4 missense, 1 in-frame duplication, 3 frameshift variants)
6
Observational data: associations, not effects.
Further findings
Diagnostic delay from DM onset to WS1 diagnosis · significantly shorter in screened group
p ≈ 0.015
- Age at admission for diabetes mellitus (DM) · younger in historical cases
- P = 0.04
- Age at WS1 diagnosis · no statistically significant difference
- P = 0.191
Original publication
Diabetes Insipidus as an Early Clinical Indicator of Wolfram Syndrome Type 1: Evidence From a Symptom‐Based Screening Approach. Pediatr Diabetes. Published 2 October 2025. doi:10.
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