Development of Obesity following Treatment for Childhood Malignancies
Authors' conclusion
Higher risk for developing overweight/obesity face the CCS who had increased BMI at diagnosis, were younger than 6 years of age, received cranial radiation therapy even as low as 6 Gys, had tumors and surgery of the hypothalamic-pituitary region, craniopharyngioma and those who were treated with dexamethasone. They also have high likelihood of developing metabolic syndrome.
Study context
- Population
- Childhood cancer survivors (CCSs), including after treatment for childhood malignancies and craniopharyngioma
- Outcome
- Risk factors for overweight/obesity in CCSs
Main finding
As reported in the abstract
- Higher risk of overweight/obesity in CCSs with increased body mass index (BMI) at diagnosis, age <6 years, cranial radiation therapy even as low as 6 Gys, hypothalamic-pituitary tumors and surgery, craniopharyngioma, or dexamethasone treatment
- These CCSs also have high likelihood of developing metabolic syndrome
Further findings
Possible mechanisms of increased BMI
- Hypothalamic hyperphagia and hypothalamic-pituitary insufficiency, corticosteroid therapy, constitutional factors incl. genetic predisposition and variable sensitivity to corticosteroids
Original publication
Development of Obesity following Treatment for Childhood Malignancies. Horm Res Paediatr. Published 10 March 2025. doi:10.
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