Development of a new health-related quality of life measure for people with diabetes who experience hypoglycaemia: the Hypo-RESOLVE QoL
Authors' conclusion
The Hypo-RESOLVE QoL is a rigorously developed patient-reported outcome measure assessing the health-related quality of life impacts of hypoglycaemia. The Hypo-RESOLVE QoL has demonstrable validity and reliability and has value for use in clinical decision-making and as a clinical trial endpoint.
Study context
- Population
- People with diabetes who experience hypoglycaemiaStage 3 survey
- Participants
- 1,246 people
- Outcome
- Psychometric performance of the final 14-item Hypo-RESOLVE QoL
Methodological detailssemi-structured interviews, cognitive debriefing interviews, cross-sectional observational survey, Stage 1: semi-structured interviews (N=31), Stage 2: cognitive debriefing interviews (N=70 people with diabetes; N=14 clinicians)
- Semi-structured interviews
- Cognitive debriefing interviews
- Cross-sectional observational survey
- Stage 1: semi-structured interviews (N=31)
- Stage 2: cognitive debriefing interviews (N=70 people with diabetes; N=14 clinicians)
Performance
As reported in the abstract
- Final measure items (from 76-item draft)
- 14
- Structural validity χ2
- 472.27, df=74, p<0.001
- Comparative fit index
- 0.943
- Root mean square error of approximation
- 0.069
- Convergent validity with related constructs (r)
- 0.46-0.59
- Internal consistency (α)
- 0.91
- Test-retest reliability (intraclass correlation coefficient)
- 0.87
Further findings
Conceptual model of hypoglycaemia-related health-related quality of life
- Themes, organised by physical, social and psychological aspects
- 19
Original publication
Development of a new health-related quality of life measure for people with diabetes who experience hypoglycaemia: the Hypo-RESOLVE QoL. Diabetologia. Published 22 May 2024. doi:10.
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