Determination of time in range associated with HbA1c ≤ 6.5% in Latin American pregnant women diagnosed with type 1 diabetes mellitus using an automated insulin delivery system
Authors' conclusion
The correlation between HbA1c and %TIR during pregnancy was weak. The optimal cutoff points for identifying patients with HbA1c < 6.0% and < 6.5% were %TIR > 66.1% and > 61.1%, respectively, with moderate sensitivity and specificity.
Study context
- Population
- Pregnant women with T1D using an AID system in Colombia and Chile; mean age 31.8 ± 6.2 years, pregestational HbA1c 7.2% (IQR 6.5–8.2)
- Participants
- 52 women
- Outcome
- Correlation between %TIR and HbA1c
Methodological detailsprospective cohort
- Prospective cohort
Performance
As reported in the abstract
Correlation between %TIR and HbA1c and discriminating capacity of %TIR for HbA1c thresholds
- Spearman's rank correlation coefficient, %TIR vs HbA1c, all gestation (weak, negative; p:0.0329)
- −0.22
- Correlation, second trimester (p: 0.38)
- −0.13
- Correlation, third trimester (p = 0.08)
- −0.26
- AUC of %TIR for predicting HbA1c < 6%
- 0.59 (95% CI 0.46-0.72; poor)
- AUC of %TIR for predicting HbA1c < 6.5%
- 0.57 (95% CI 0.44-0.70; poor)
- Optimal %TIR cutoff for HbA1c < 6% (65% sensitivity, 62% specificity)
- > 66.1%
- Optimal %TIR cutoff for HbA1c < 6.5% (59% sensitivity, 54% specificity)
- > 61.1%
Further findings
- HbA1c, second trimester (IQR 5.9,7.1)
- 6.40%
- HbA1c, third trimester (IQR 5.9,6.8)
- 6.25%
Original publication
Determination of time in range associated with HbA1c ≤ 6.5% in Latin American pregnant women diagnosed with type 1 diabetes mellitus using an automated insulin delivery system. Diabetes Res Clin Pract. Published 13 May 2023. doi:10.
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