Determinants of excessive weight gain after the initiation of insulin therapy in type 2 diabetes mellitus: Retrospective inception cohort study (ZODIAC 60)
Authors' conclusion
Clinicians and patients should be alert for excessive weight gain after initiation of insulin, in the case of weight loss prior to insulin therapy initiation, particularly with increasing and prolonged high HbA1c at (and after) insulin initiation.
Study context
- Population
- Patients with T2D initiating insulin therapy
- Participants
- 5,086 patients
- Outcome
- Excessive weight gain (5 kg or more) after insulin initiation
- Follow-up
- First year after initiation of insulin therapy
Methodological detailsobservational, new user design/inception cohort, Logistic regression with subsequent ROC analyses; determinants pre-, at- and post-insulin initiation
- Observational
- New user design/inception cohort
- Logistic regression with subsequent ROC analyses; determinants pre-, at- and post-insulin initiation
Main finding
As reported in the abstract
Excessive weight gain (≥5 kg) · first year after insulin initiation
- Patients who gained 5 kg or more
- 10.0%
- Earliest determinants: weight change (inversely) and HbA1c change in the 2 years pre-insulin
- p < 0.001
Observational data: associations, not effects.
Further findings
Excessive weight gain in patients who lost weight parallel with HbA1c rise in the 2 years pre-insulin
- Most pronounced weight gain; gained 5 kg or more
- 20.3%
Original publication
Determinants of excessive weight gain after the initiation of insulin therapy in type 2 diabetes mellitus: Retrospective inception cohort study (ZODIAC 60). Diabetes Res Clin Pract. Published 19 May 2023. doi:10.
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