Effect of a lifestyle intervention to prevent weight gain at initiation of insulin pump therapy in type 2 diabetes: A randomized, controlled, multicentre trial
Authors' conclusion
Treatment intensification by insulin pump therapy in patients with type 2 diabetes is effective to improve glycaemic control. A gain of about 1 kg per 1 % drop in HbA1c can be expected after insulin treatment intensification. This weight gain was not prevented by a home-base, individualized, 6-months lifestyle intervention program.
Study context
- Population
- Individuals with T2D initiating insulin pump therapy
- Participants
- 54 individuals
- Comparison
- 6-month dietary and physical activity intervention vs usual care at initiation of insulin pump therapy
- Primary endpoint
- Between-group difference in weight gain
- Follow-up
- 6 months
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Weight gain
P = 0.56
Further findings
HbA1c
- HbA1c improved without difference between groups
Weight gain per 1% decrease in HbA1c (post-hoc multivariate analysis, all participants)
- Weight increase per 1% HbA1c decrease, kg (95% CI 0.47; 1.41), p < 0.001
- 0.94
- Weight gain independently associated with younger age, active smoking and magnitude of HbA1c reduction
- Post-hoc
Original publication
Effect of a lifestyle intervention to prevent weight gain at initiation of insulin pump therapy in type 2 diabetes: A randomized, controlled, multicentre trial. Diabetes Res Clin Pract. Published 9 May 2023. doi:10.
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