Depressive Symptoms Longitudinally Mediate the Effect of Hyperglycemia on Memory Decline in Type 2 Diabetes
Authors' conclusion
Incident elevations in depressive symptoms mediated the longitudinal association between hyperglycemia and 6-year episodic memory scores. For older adults with T2D, interventions to prevent HbA1c-related incident depressive symptoms may be beneficial in reducing the neurotoxic effects of chronic hyperglycemia on cognition.
Study context
- Population
- Older adults (aged ≥51 years) with self-reported T2D in the U.S.-wide Health and Retirement Study; baseline mean age 69.4 (SD = 9.1), mean HbA1c 7.2% (SD = 1.4%), 55.0% women
- Participants
- 2,155 adults
- Outcome
- Mediating role of changes in depressive symptoms in the association between baseline HbA1c and episodic memory
- Follow-up
- 6 years
Methodological detailsmediation analysis, observational, structural equation modeling, Adjusted for sociodemographics, chronic comorbidities, medication adherence, enrollment year, and prior depressive symptoms and memory scores
- Mediation analysis
- Observational
- Structural equation modeling
- Adjusted for sociodemographics, chronic comorbidities, medication adherence, enrollment year, and prior depressive symptoms and memory scores
Main finding
As reported in the abstract
Mediation of HbA1c effect on memory by depressive symptoms
Proportion of longitudinal effect of HbA1c on memory accounted for by depressive symptoms
19%
Observational data: associations, not effects.
Further findings
- Sensitivity analyses ruled out alternative directions of associations
Original publication
Depressive Symptoms Longitudinally Mediate the Effect of Hyperglycemia on Memory Decline in Type 2 Diabetes. Diabetes Care. Published 25 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →