Depressive symptoms and mortality – effect variation by body mass index: a prospective study in a primary care population
Authors' conclusion
Effect of increased depressive symptoms on all-cause mortality risk seems to vary with BMI. Elevated mortality risk is especially apparent among depressive subjects with normal weight. Among individuals with overweight and obesity, increased depressive symptoms seem not to further increase all-cause mortality.
Study context
- Population
- Middle-aged subjects with elevated cardiovascular risk identified by a population survey, Finnish primary care3,072 identified
- Participants
- 2,509 subjects
- Exposure
- Increased depressive symptoms vs none, by body mass index (BMI) category
- Outcome
- All-cause mortality
- Follow-up
- 14 years
Methodological detailsprimary care setting
- Primary care setting
Main finding
As reported in the abstract
All-cause mortality by BMI category · 14 years
Each group vs without increased depressive symptomsEstimate (95% CI)
Increased depressive symptoms
HR (BMI <25.0 kg/m²) 3.26(1.83–5.82)
Increased depressive symptoms
HR (BMI 25.0-29.9 kg/m²) 1.31(0.83–2.06)
Increased depressive symptoms
HR (BMI 30.0-34.9 kg/m²) 1.27(0.76–2.11)
Increased depressive symptoms
HR (BMI ≥35.0 kg/m²) 1.25(0.63–2.48)
Observational data: associations, not effects.
Original publication
Depressive symptoms and mortality – effect variation by body mass index: a prospective study in a primary care population. Int J Obes (Lond). Published 28 March 2023. doi:10.
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