Metabolic surgery-induced changes of the growth hormone system relate to improved adipose tissue function
Authors' conclusion
Reversal of alterations of the GH-IGF-1 axis after surgically-induced weight loss is unlikely related to improved leptin secretion and/or insulin sensitivity, but is rather associated with restored adipose tissue function and reduced low-grade inflammation.
Study context
- Population
- People with obesity undergoing bariatric (metabolic) surgery and lean healthy controls
- Participants
- 79 vs 24
- Exposure
- People with obesity before and after metabolic surgery vs lean healthy controls
- Obesity (OBE)n = 79
- CONn = 24reference
- Outcome
- GH-IGF-1 axis after metabolic surgery
- Follow-up
- 52 weeks
Methodological detailslongitudinal, before and 2, 12, 24 and 52 weeks after metabolic surgery, lean healthy control comparison, hyperinsulinemic-euglycemic clamps
- Longitudinal, before and 2, 12, 24 and 52 weeks after metabolic surgery
- Lean healthy control comparison
- Hyperinsulinemic-euglycemic clamps
Main finding
As reported in the abstract
OBE lost body weight
33%
Observational data: associations, not effects.
Further findings
Baseline OBE vs CON
- OBE had higher glycemia and leptinemia and pronounced peripheral, adipose tissue and hepatic insulin resistance vs CON
- Growth hormone (GH) and IGF-binding proteins (IGFBP1) lower in OBE; IGF1 comparable between groups
Original publication
Metabolic surgery-induced changes of the growth hormone system relate to improved adipose tissue function. Int J Obes (Lond). Published 23 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →