Gestational diabetes & diabetes in pregnancy
Decreased complexity of glucose time series index associated with adverse pregnancy outcomes in gestational diabetes mellitus
Main finding · Composite adverse outcomesResult — go to the resultOdds ratio 12.10 95% CI 4.41–33.18Authors' conclusion
A lower CGI during pregnancy was associated with composite adverse outcomes and LGA. CGI, a novel glucose homeostasis predictor, seems to be superior to conventional glucose indicators for the prediction of adverse pregnancy outcomes in women with GDM.
Study context
- Population
- Singleton pregnant women with gestational diabetes mellitus (GDM) undergoing continuous glucose monitoring (CGM) at a median of 26.86 gestational weeks
- Participants
- 388 women
- Exposure
- Low vs middle vs high complexity of glucose time series index tertiles
- Outcome
- Composite:
- Adverse outcomes
- Large for gestational age (LGA)
Main finding
Composite adverse outcomes
Odds ratio
12.10
95% CI 4.41–33.18
Low CGIvs High CGI
OR 12.10 (95% CI 4.41–33.18)
As reported in the abstract
- Composite adverse outcomes, all participants
- 63 (16.2%)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| LGALow CGIvs High CGIAdjusted for confounders | 12.68 (4.04–39.75) | |
| 0.050.21520Odds ratio (log scale) |
- Large for gestational age (LGA) — LGA infants, all participants
- 71 (18.3%)
Prediction of adverse pregnancy outcomes (ROC analysis)
- CGI significantly better than HbA1c and conventional CGM indicators
- all p < .05
Original publication
Decreased complexity of glucose time series index associated with adverse pregnancy outcomes in gestational diabetes mellitus. Diabetes Obes Metab. Published 21 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →