Declining Incidence Rates of Distal Symmetric Polyneuropathy in People With Type 1 and Type 2 Diabetes in Denmark, With Indications of Distinct Patterns in Type 1 Diabetes
Authors' conclusion
Incidence rates for DSPN are declining in type 1 and type 2 diabetes, possibly due to improved diabetes treatment. This causality remains to be explored. Distinct age-related patterns indicate that the pathophysiology of DSPN may differ between diabetes types.
Study context
- Population
- Individuals with T1D or T2D at a Danish tertiary diabetes center, 1996–2018, without prevalent distal symmetric polyneuropathy (DSPN); vibration perception threshold by biothesiometry9,473 analysed (>25 V)
- Participants
- 19,342 individuals
- Exposure
- DSPN incidence by calendar time, T1D and T2D
- Outcome
- Incidence rate of DSPN (vibration perception threshold >25 V; also age-, sex- and height-specific cutoff)
- Follow-up
- 1996 to 2018
Methodological detailssingle tertiary diabetes centre, Poisson regression
- Single tertiary diabetes centre
- Poisson regression
Main finding
As reported in the abstract
DSPN incidence rate (>25 V cutoff), 1996 to 2018
40-year-old men with T1D: 1996 → 2018, per 100 PY
4.78 (3.60-6.33) → 1.15 (0.91-1.47) (95% CI)
60-year-old men with T2D: 1996 → 2018, per 100 PY
16.54 (11.80-23.18) → 8.02 (6.63-9.69) (95% CI)
Observational data: associations, not effects.
Further findings
DSPN incidence with age-, sex- and height-specific cutoff
- Similar incidence patterns by calendar time without sex differences
- 2,783 analysed
DSPN incidence by age in T1D
- Decreasing incidence rates with older age in T1D
Original publication
Declining Incidence Rates of Distal Symmetric Polyneuropathy in People With Type 1 and Type 2 Diabetes in Denmark, With Indications of Distinct Patterns in Type 1 Diabetes. Diabetes Care. Published 30 August 2023. doi:10.
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