Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery
Authors' conclusion
The findings from this experiment further implicate the coagulation and immune system in ME/CFS, and bring to attention the pathology of or imposed on the endothelium.
Study context
- Population
- People with ME/CFS and controls not previously infected with SARS-CoV-2
- Participants
- 15 vs 10
- Comparison
- ME/CFS vs controls
- ME/CFSn = 15
- Controlsn = 10reference
- Outcome
- Differences in protein expression in platelet-poor plasma
Methodological detailsDIA LC-MS/MS proteomics, platelet-poor plasma
- DIA LC-MS/MS proteomics
- Platelet-poor plasma
Main finding
As reported in the abstract
Differentially expressed plasma proteins, ME/CFS vs controls
Proteins significantly increased in ME/CFS vs controls
24
Proteins significantly downregulated in ME/CFS vs controls
21
Original publication
Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery. Cardiovasc Diabetol. Published 16 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →