Dapagliflozin Alters Plasma Metabolome in Patients With Type 1 Diabetes During Ketosis
Authors' conclusion
In adults with T1D, dapagliflozin alters TCA cycle metabolites, amino acid metabolites and certain lipids during insulin withdrawal.
Study context
- Population
- Adults with T1D undergoing supervised insulin withdrawal
- Participants
- 17 adults
- Comparison
- Dapagliflozin vs usual care during ketosis induced by insulin withdrawal
- Outcome
- Plasma metabolome and lipidome during insulin withdrawal
Methodological detailssupervised insulin withdrawal
- Supervised insulin withdrawal
Main finding
As reported in the abstract
- Plasma glucose lower and ketones higher after insulin withdrawal with DP vs usual care (UC)
- DP altered amino acids and TCA cycle metabolites during ketosis
- DP increased citrate and aconitate at baseline, with a trend towards increased branched chain ketoacids and acylcarnitines
- Citrate, aconitate, α-ketoglutarate and malate increased during insulin withdrawal after UC; after DP α-ketoglutarate and malate unchanged, and fumarate and succinate significantly decreased
- Acetylcarnitine significantly higher during insulin withdrawal after DP vs UC
- DP effected subtle changes in amino acids and amino acid derivatives
- Symmetric dimethylarginine and pseudouridine significantly elevated at baseline and after insulin withdrawal after DP
- Increased very long TG species with DP and differences in phospholipids, particularly phosphatidylcholine
Original publication
Dapagliflozin Alters Plasma Metabolome in Patients With Type 1 Diabetes During Ketosis. Diabetes Obes Metab. Published 28 September 2026. doi:10.
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