Daily glucose variability is associated with intrahepatic fat content, β cell sensitivity, and biomarkers of glycolysis in youth with obesity
Authors' conclusion
Daily glucose variability is associated with the degree of intrahepatic fat content, postprandial glucose, and plasma lactate concentrations.
Study context
- Population
- Youth with obesity (11 girls; BMI percentile median 99.0 [25th–75th percentiles 97.9–99.0]) wearing CGM for 10 days and undergoing a 3-h OGTT; β cell function by oral minimal model, liver proton density fat fraction by MRI
- Participants
- 27 participants
- Outcome
- Associations of CGM glucose variability with liver fat, β cell function and glycolysis
Main finding
As reported in the abstract
- Average sensor glucose associated with liver proton density fat fraction
- p = 0.0130
- Glucose SD associated with liver proton density fat fraction
- p = 0.0005
- Glucose coefficient of variation (CV) associated with liver proton density fat fraction
- p = 0.0028
- First-phase insulin secretion associated with SD / CV
- p = 0.0344 / p = 0.0128
- Basal insulin secretion associated with SD / CV
- p = 0.0091 / p = 0.0012
- Insulin sensitivity associated with SD / CV
- p = 0.0031 / p = 0.0022
- 2-h glucose associated with SD / CV
- p = 0.0067 / p = 0.0324
- Plasma lactate associated with SD / CV
- p = 0.0030 / p = 0.0123
Observational data: associations, not effects.
Original publication
Daily glucose variability is associated with intrahepatic fat content, β cell sensitivity, and biomarkers of glycolysis in youth with obesity. Obesity (Silver Spring). Published 10 December 2024. doi:10.
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