Cytokines and chemokines modulate the growth of pituitary adenoma/neuroendocrine tumors: preliminary results of a monocenter prospective pilot study
Authors' conclusion
Our preliminary results support that in PAs/PitNETs, the cytokines and chemokines generate an immune network, that may contribute to regulating the cell proliferation and pattern of growth.
Study context
- Population
- Patients with PAs/PitNETs who underwent surgical removal at the Neurosurgery Division, January–June 2023of 72 operated
- Participants
- 16 patients
- Outcome
- Cytokine and chemokine expression in PAs/PitNETs (42 investigated) and tumor behavior
Methodological detailsmonocenter
- Monocenter
Main finding
As reported in the abstract
- Growth-regulated oncogene (GRO)/CXCL1 expression higher in invasive vs not-invasive tumors
- p = 0.01
- Thymus- and activation-regulated chemokine (TARC)/CCL17 expression higher in invasive vs not-invasive tumors
- p = 0.002
- Epidermal growth factor (EGF) expression higher in invasive vs not-invasive tumors
- p = 0.002
- EGF expression higher in tumors with MIB1 > 3% vs MIB1 < 3%
- p = 0.014
- Positive correlation EGF and CXCL1
- p = 0.003, r: 0.7
- Positive correlation EGF and GRO-a
- p = 0.01, r:0.61
- Positive correlation tumor-infiltrating CD68 + macrophages and CCL2 expression
- p = 0.008, r = 0.695
Observational data: associations, not effects.
Original publication
Cytokines and chemokines modulate the growth of pituitary adenoma/neuroendocrine tumors: preliminary results of a monocenter prospective pilot study. Pituitary. Published 10 March 2025. doi:10.
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